Trusted Tiny Things : Making Devices in Smart Cities More Transparent

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Interrogating Capabilities of IoT Devices

This research is supported by the UK Research Councils’ Digital Economy IT as a Utility Network+ (EP/K003569/1) and the dot.rural Digital Economy Hub (EP/G066051/1).Postprin

What Does this Device Do?

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Třetí rozměr ve vizualizaci hluku - Návrh nových metod pro vizualizace spojitých jevů

3D kartografická vizualizace souvislého časově závislého jevu není snadný úkol. Zaměření tohoto výzkumu je motivováno snahou o vizualizaci právě takového jevu. Na základě současného stavu poznání jsme implementovali nové vizualizační metody pro vizualizaci spojitých časově závislých jevů. Všechny vizualizace jsou vytovřeny pro aplikaci v oblasti hluku generovaného silniční dopravou ve městě. Všechny vizualizace využívají třetí rozměr mapové scény. První dvě metody se zaměřují na změny hluku ve vertikálním rozměru (tj. ve výšce). Třetí metoda vychází z principu space–time cube (tzv. časoprostorové krychle), a proto využívá časovou proměnnou jako třetí rozměr. Pro demonstrační účely byly všechny metody implementovány v online aplikaci. Dále bylo provedeno uživatelské testování těchto aplikací. Tento článek tedy popisuje návrh, implementaci a uživatelské hodnocení nově navržených metod pro vizualizaci třetího rozměru.3D cartographic visualization of a continuous time-dependent phenomenon is not an easy task. The focus of this research is motivated by the struggle to visualize such a phenomenon. Based on the current state of the art, we implemented new visualization methods to visualize continuous time-dependent phenomena. All visualizations are based on the use case of road-traffic-generated noise in outdoor urban areas. These visualizations utilize the third dimension of the map scene. The first two methods focus on the variations of the noise in the vertical dimension (i.e. height). The third method is based on the idea of space–time cube and therefore utilizes the time variable as the third dimension. For demonstration purposes, all methods were implemented in an online application. Furthermore, user testing of those applications was conducted. This paper thus describes design, implementation and user evaluation of newly proposed methods for third dimension visualization

The Third Dimension in Noise Visualization–a Design of New Methods for Continuous Phenomenon Visualization

3D cartographic visualization of a continuous time-dependent phenomenon is not an easy task. The focus of this research is motivated by the struggle to visualize such a phenomenon. Based on the current state of the art, we implemented new visualization methods to visualize continuous time-dependent phenomena. All visualizations are based on the use case of road-traffic-generated noise in outdoor urban areas. These visualizations utilize the third dimension of the map scene. The first two methods focus on the variations of the noise in the vertical dimension (i.e. height). The third method is based on the idea of space–time cube and therefore utilizes the time variable as the third dimension. For demonstration purposes, all methods were implemented in an online application. Furthermore, user testing of those applications was conducted. This paper thus describes design, implementation and user evaluation of newly proposed methods for third dimension visualization.Urban Data Scienc

Chronic Hepatitis C Virus Infection Modulates the Transcriptional Profiles of CD4+ T Cells

Background. Chronic hepatitis C (CHC) is associated with altered cell-mediated immune response. Objective. The aim of the study was to characterize functional alterations in CD4+ T cell subsets and myeloid-derived suppressor cells (MDSCs) during chronic hepatitis C virus (HCV) infection. Methodology. The expression levels of the lineage-defining transcriptional factors (TFs) T-bet, Gata3, Rorγt, and Foxp3 in circulating CD4+ T cells and percentages of MDSCs in peripheral blood were evaluated in 33 patients with CHC, 31 persons, who had spontaneously cleared the HCV infection, and 30 healthy subjects. Analysis. The CD4+ T cells TFs T-bet (T-box expressed in T cells), Foxp3 (Forkhead box P3 transcription factor), Gata3 (Gata-binding protein 3), and Rorγt (retinoic-acid-related orphan receptor gamma) and activation of CD8+ T cells, as well as percentages of MDSCs, were measured by multicolor flow cytometry after intracellular and surface staining of peripheral blood mononuclear cells with fluorescent monoclonal antibodies. Result. The patients with CHC had significantly lower percentages of CD4+ T cells expressing Rorγt and Gata3 and higher percentages of Foxp3-expressing CD4+ T cells than healthy controls and persons who spontaneously cleared HCV infection. The ratios of T-bet+/Gata3+ and Foxp3+/Rorγt+ CD4+ T cells were the highest in the patients with CHC. In the patients with CHC, the percentages of Gata3+ and Rorγt+ CD4+ T cells and the percentages of T-bet+ CD4+ T cells and CD38+/HLA-DR+ CD8+ T cells demonstrated significant positive correlations. In addition, the percentage of CD38+/HLA-DR+ CD8+ T cells correlated negatively with the percentage of MDSCs. Conclusion. Chronic HCV infection is associated with downregulation of TFs Gata3 and Rorγt polarizing CD4+ T cells into Th2 and Th17 phenotypes together with upregulation of Foxp3 responsible for induction of regulatory T cells suppressing immune response